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By Nick Loman on August 10, 2012
After its launch in 2005, the 454 rapidly became the go-to technology if you wanted to sample diversity in amplicon libraries, whether a cancer panel, a viral quasispecies or microbial community profiling. It is not difficult to see why. Compared to Sanger sequencing the 454 offered massive throughput, being able to produce over a million reads [...]